Leases, Licensed Technology and Other Commitments	12 Months Ended
Dec. 31, 2012
Leases, Licensed Technology and Other Commitments	8. Leases, Licensed Technology and Other Commitments Facility Leases The Company conducts the majority of its operations in a 100,000 square foot office and laboratory facility under a non-cancelable operating lease that extends to July 2019 with two consecutive five-year renewal options. The Company maintains an outstanding letter of credit of $699,000 in accordance with the terms of the amended lease. In May 2012, the Company entered into a three-year operating lease agreement for an additional 26,000 square feet of office space. Rent expense, net of sublease income of $6,000 in 2012, $67,000 in 2011 and $28,000 in 2010, amounted to $5.9 million, $2.0 million and $2.1 million in 2012, 2011 and 2010, respectively. Future non-cancelable minimum annual rental payments through July 2019 under these leases are $6.5 million in 2013, $6.7 million in 2014, $6.2 million in 2015, $5.5 million in 2016, $5.6 million in 2017, and $9.0 million thereafter. In January 2013, the Company entered into a lease agreement for approximately 244,000 square feet of laboratory and office space in two adjacent, connected buildings under construction in Cambridge, Massachusetts, which is expected to be available for occupancy in early 2015. The term of the lease will be for 15 years from substantial completion of the buildings with options to renew for three terms of five years each. The Company has rights and options to expand into additional space in the buildings through June 2014. The base rent is subject to increases over the term of the lease. Non-cancelable minimum annual lease payments for the annual periods beginning upon commencement of the lease are $5.2 million, $6.3 million, $16.9 million, $19.3 million and $19.6 million in the first five years of the lease and $220.3 million thereafter, plus the Company’s share of the facility operating expenses. The Company has established a letter of credit as security for the lease of approximately $5.8 million upon signing of the lease, which was supported by restricted cash in January 2013. In addition, in January 2013, the Company entered into a lease agreement for approximately 22,000 square feet of office space in a building under construction in Lausanne, Switzerland, which is expected to be available for occupancy in early 2014. The term of the lease will be ten years, with options for extension of the term and an early termination at the Company’s option after five years. Non-cancelable minimum annual lease payments are expected to be approximately $1.1 million per year for the first five years of the lease and $5.8 million thereafter. Licensed Technology The Company has entered into agreements with several universities under the terms of which the Company has received exclusive licenses to technology and intellectual property. The agreements, which are generally cancelable by the Company, provide for the payment of license fees and/or minimum payments, which are generally creditable against future royalties. Fees paid by the Company amounted to $145,000 in each of 2012, 2011 and 2010, and are expected to amount to $145,000 in 2013 and thereafter. In addition, the agreements provide for payments upon the achievement of certain milestones in product development. The agreements also require the Company to fund certain costs associated with the filing and prosecution of patent applications. Other Commitments The Company has entered into various employment agreements with eighteen officers of the Company. The agreements for these officers have remaining terms as of December 31, 2012 through the end of 2013, providing for aggregate base salaries of $5.7 million for 2013.

8. Leases, Licensed Technology and Other Commitments

Facility Leases

The Company conducts the majority of its operations in a 100,000 square foot office and laboratory facility under a non-cancelable operating lease that extends to July 2019 with two consecutive five-year renewal options. The Company maintains an outstanding letter of credit of $699,000 in accordance with the terms of the amended lease. In May 2012, the Company entered into a three-year operating lease agreement for an additional 26,000 square feet of office space. Rent expense, net of sublease income of $6,000 in 2012, $67,000 in 2011 and $28,000 in 2010, amounted to $5.9 million, $2.0 million and $2.1 million in 2012, 2011 and 2010, respectively. Future non-cancelable minimum annual rental payments through July 2019 under these leases are $6.5 million in 2013, $6.7 million in 2014, $6.2 million in 2015, $5.5 million in 2016, $5.6 million in 2017, and $9.0 million thereafter.

In January 2013, the Company entered into a lease agreement for approximately 244,000 square feet of laboratory and office space in two adjacent, connected buildings under construction in Cambridge, Massachusetts, which is expected to be available for occupancy in early 2015. The term of the lease will be for 15 years from substantial completion of the buildings with options to renew for three terms of five years each. The Company has rights and options to expand into additional space in the buildings through June 2014. The base rent is subject to increases over the term of the lease. Non-cancelable minimum annual lease payments for the annual periods beginning upon commencement of the lease are $5.2 million, $6.3 million, $16.9 million, $19.3 million and $19.6 million in the first five years of the lease and $220.3 million thereafter, plus the Company’s share of the facility operating expenses. The Company has established a letter of credit as security for the lease of approximately $5.8 million upon signing of the lease, which was supported by restricted cash in January 2013.

In addition, in January 2013, the Company entered into a lease agreement for approximately 22,000 square feet of office space in a building under construction in Lausanne, Switzerland, which is expected to be available for occupancy in early 2014. The term of the lease will be ten years, with options for extension of the term and an early termination at the Company’s option after five years. Non-cancelable minimum annual lease payments are expected to be approximately $1.1 million per year for the first five years of the lease and $5.8 million thereafter.

Licensed Technology

The Company has entered into agreements with several universities under the terms of which the Company has received exclusive licenses to technology and intellectual property. The agreements, which are generally cancelable by the Company, provide for the payment of license fees and/or minimum payments, which are generally creditable against future royalties. Fees paid by the Company amounted to $145,000 in each of 2012, 2011 and 2010, and are expected to amount to $145,000 in 2013 and thereafter. In addition, the agreements provide for payments upon the achievement of certain milestones in product development. The agreements also require the Company to fund certain costs associated with the filing and prosecution of patent applications.

Other Commitments

The Company has entered into various employment agreements with eighteen officers of the Company. The agreements for these officers have remaining terms as of December 31, 2012 through the end of 2013, providing for aggregate base salaries of $5.7 million for 2013.