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Investments - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Mar. 04, 2015
Sep. 30, 2018
Mar. 31, 2018
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Investments Equity Securities [Abstract]            
Purchase of common stock, value       $ 500 $ 0 $ 0
Investment impairment charges       $ (4,678)    
Bone Biologics Inc [Member]            
Investments Equity Securities [Abstract]            
Warrants held for share purchases       13,000    
Weighted average exercise price of warrant       $ 14.32    
Warrants exercisable period       7 years    
Warrant expiration year       2020    
Purchase of common stock, value     $ 500      
Bone Biologics Inc [Member] | Common Stock [Member]            
Investments Equity Securities [Abstract]            
Purchase of stock, shares     25,000      
Bone Biologics Inc [Member] | ASU 2016-01 [Member] | CommonStock and Warrants [Member]            
Investments Equity Securities [Abstract]            
Investment impairment charges   $ 4,400        
eNeura Note [Member] | eNeura Inc [Member]            
Debt Instrument [Line Items]            
Non-refundable fees paid $ 300          
Accrued interest rate on promissory note 8.00%          
Maturity description of Promissory note       The eNeura Note will mature on March 4, 2019    
Debt Instrument, Maturity Date       Mar. 04, 2019    
eNeura Note [Member] | eNeura Inc [Member] | Convertible Debt Securities [Member]            
Debt Instrument [Line Items]            
Principal amount of promissory note $ 15,000          
eNeura Note [Member] | eNeura Inc [Member] | Preferred Stock [Member]            
Debt Instrument [Line Items]            
Conversion price per share       $ 7.30    
eNeura Note [Member] | eNeura Inc [Member] | Minimum [Member]            
Debt Instrument [Line Items]            
Third party acquisition       50.00%