The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M Company COM 88579Y101 901 8,236 SH   OTR   7,356 0 880
Accelrys, Inc. COM 00430U103 2,063 245,645 SH   OTR   245,645 0 0
Achillion Pharmaceuticals Inc. COM 00448Q201 837 102,312 SH   OTR   102,312 0 0
Aflac Incorporated COM 001055102 896 15,411 SH   OTR   13,511 0 1,900
Akorn, Inc. COM 009728106 1,352 100,000 SH   DFND   100,000 0 0
Akorn, Inc. COM 009728106 10,715 792,560 SH   OTR   750,210 0 42,350
Alcatel Lucent Spons ADR SPONSORED ADR 013904305 1,820 1,000,000 SH   DFND   1,000,000 0 0
Alcatel Lucent Spons ADR SPONSORED ADR 013904305 5,766 3,168,369 SH   OTR   2,879,414 0 288,955
Align Technology Inc. COM 016255101 818 22,076 SH   OTR   22,076 0 0
Alkermes PLC SHS G01767105 1,206 42,034 SH   OTR   42,034 0 0
Amarin Corp. PLC ADS SPONS ADR NEW 023111206 825 142,204 SH   OTR   126,984 0 15,220
American Express Company COM 025816109 968 12,952 SH   OTR   11,267 0 1,685
Angiodynamics, Inc. COM 03475V101 2,133 189,116 SH   OTR   167,728 0 21,388
Aratana Therapeutics, Inc. COM 03874P101 403 53,295 SH   OTR   53,295 0 0
Array Biopharma Inc. COM 04269X105 4,177 920,000 SH   DFND   920,000 0 0
Array Biopharma Inc. COM 04269X105 12,109 2,667,128 SH   OTR   2,557,563 0 109,565
AtriCure Inc. COM 04963C209 4,150 436,822 SH   OTR   421,417 0 15,405
Autozone Inc. COM 053332102 837 1,975 SH   OTR   1,720 0 255
BioMarin Pharmaceutical Inc. COM 09061G101 743 13,337 SH   OTR   13,337 0 0
BlackRock Inc. COM 09247X101 981 3,820 SH   OTR   3,345 0 475
Bristol Myers Squibb Co. COM 110122108 219 4,895 SH   OTR   4,895 0 0
Cardiome Pharma Corp. COM NO PAR 14159U301 34 17,280 SH   OTR   17,280 0 0
Celldex Therapeutics Inc. COM 15117B103 2,106 134,915 SH   OTR   134,915 0 0
Cepheid Inc. COM 15670R107 1,355 39,368 SH   OTR   39,368 0 0
Constant Contact, Inc. COM 210313102 1,832 114,021 SH   OTR   101,881 0 12,140
Covidien PLC Ordinary Shares SHS G2554F113 747 11,884 SH   OTR   11,884 0 0
Cummins Inc. COM 231021106 797 7,345 SH   OTR   6,425 0 920
Cytokinetics Inc COM 23282W100 1,242 107,343 SH   OTR   107,343 0 0
Datalink Corp. COM 237934104 106 10,000 SH   DFND   10,000 0 0
Datalink Corp. COM 237934104 4,232 397,727 SH   OTR   358,529 0 39,198
Eastman Chemical Co. COM 277432100 838 11,965 SH   OTR   10,335 0 1,630
Emcore Corp. COM NEW 290846203 4,820 1,338,750 SH   DFND   1,338,750 0 0
Emcore Corp. COM NEW 290846203 4,605 1,279,046 SH   OTR   1,273,910 0 5,136
Endologix Inc. COM 29266S106 827 62,255 SH   OTR   62,255 0 0
EOG Resources, Inc. COM 26875P101 728 5,530 SH   OTR   4,725 0 805
Exxon Mobil Corporation COM 30231G102 869 9,619 SH   OTR   8,351 0 1,268
Finisar Corp. COM NEW 31787A507 7,045 415,625 SH   DFND   415,625 0 0
Finisar Corp. COM NEW 31787A507 11,882 700,981 SH   OTR   668,510 0 32,471
Fluidigm Corp. COM 34385P108 836 47,856 SH   OTR   47,856 0 0
GenMark Diagnostics, Inc. COM 372309104 997 96,384 SH   OTR   96,384 0 0
HealthStream, Inc. COM 42222N103 1,250 49,378 SH   OTR   49,378 0 0
HeartWare International Inc. COM 422368100 701 7,370 SH   OTR   7,370 0 0
Humana Inc. COM 444859102 265 3,145 SH   OTR   3,145 0 0
Integrated Device Technology I COM 458118106 2,292 288,682 SH   OTR   247,392 0 41,290
International Business Machines Corp. COM 459200101 775 4,054 SH   OTR   3,529 0 525
IntraLinks Holdings Inc. COM 46118H104 1,686 232,199 SH   OTR   201,189 0 31,010
JDS Uniphase Corp. COM PAR $0.001 46612J507 1,583 110,000 SH   DFND   110,000 0 0
JDS Uniphase Corp. COM PAR $0.001 46612J507 4,325 300,525 SH   OTR   291,725 0 8,800
Johnson & Johnson COM 478160104 1,079 12,563 SH   OTR   11,368 0 1,195
Lannett Co. Inc COM 516012101 1,282 107,660 SH   OTR   107,660 0 0
Life Technologies Corp. COM 53217V109 730 9,868 SH   OTR   9,868 0 0
Ligand Pharmaceuticals Inc. COM NEW 53220K504 1,847 49,379 SH   OTR   49,379 0 0
Marriott International Inc. CL A 571903202 849 21,019 SH   OTR   18,278 0 2,741
Masimo Corporation COM 574795100 779 36,764 SH   OTR   36,764 0 0
Mindspeed Technologies, Inc. COM NEW 602682205 2,203 680,000 SH   DFND   680,000 0 0
Mindspeed Technologies, Inc. COM NEW 602682205 5,938 1,832,795 SH   OTR   1,734,885 0 97,910
National Oilwell Varco Inc. COM 637071101 765 11,105 SH   OTR   9,730 0 1,375
Neogen Corp. COM 640491106 1,073 19,310 SH   OTR   19,310 0 0
NeoGenomics Inc COM NEW 64049M209 2,366 594,575 SH   OTR   594,575 0 0
Novadaq Technologies Inc. COM 66987G102 1,826 135,682 SH   OTR   135,682 0 0
NPS Pharmaceuticals Inc. COM 62936P103 847 56,045 SH   OTR   56,045 0 0
Nuvasive Inc. COM 670704105 520 20,974 SH   OTR   17,664 0 3,310
Oclaro, Inc. COM NEW 67555N206 3,371 2,857,000 SH   DFND   2,857,000 0 0
Oclaro, Inc. COM NEW 67555N206 4,572 3,874,964 SH   OTR   3,831,724 0 43,240
Omnicell Inc. COM 68213N109 7,405 360,337 SH   OTR   336,077 0 24,260
Onyx Pharmaceuticals Inc. COM 683399109 778 8,965 SH   OTR   8,965 0 0
Oplink Communications, Inc. COM NEW 68375Q403 782 45,000 SH   DFND   45,000 0 0
Oplink Communications, Inc. COM NEW 68375Q403 2,551 146,884 SH   OTR   144,914 0 1,970
Orexigen Therapeutics Inc. COM 686164104 1,249 213,752 SH   OTR   213,752 0 0
Pepsico Inc. COM 713448108 827 10,108 SH   OTR   8,848 0 1,260
Pfizer Inc. COM 717081103 207 7,400 SH   OTR   7,400 0 0
PMC-Sierra Inc. COM 69344F106 127 20,000 SH   OTR   20,000 0 0
The Procter & Gamble Company COM 742718109 755 9,813 SH   OTR   8,768 0 1,045
Quidel Corp. COM 74838J101 5,095 199,570 SH   OTR   189,090 0 10,480
Regeneron Pharmaceuticals, Inc. COM 75886F107 1,341 5,963 SH   OTR   5,235 0 728
Rochester Medical Corp. COM 771497104 1,227 83,268 SH   OTR   83,268 0 0
RTI Biologics, Inc. COM 74975N105 2,008 534,000 SH   DFND   534,000 0 0
RTI Biologics, Inc. COM 74975N105 13,299 3,536,919 SH   OTR   3,363,209 0 173,710
Ruckus Wireless Inc. COM 781220108 1,007 78,597 SH   OTR   68,137 0 10,460
Sagent Pharmaceuticals Inc. COM 786692103 960 45,763 SH   OTR   45,763 0 0
Sangamo Biosciences, Inc. COM 800677106 664 85,000 SH   DFND   85,000 0 0
Sangamo Biosciences, Inc. COM 800677106 1,841 235,700 SH   OTR   235,700 0 0
Skyworks Solutions COM 83088M102 3,049 139,283 SH   OTR   122,023 0 17,260
Southern Company COM 842587107 804 18,212 SH   OTR   15,947 0 2,265
Southwest Airlines Co. COM 844741108 892 69,171 SH   OTR   59,936 0 9,235
SPDR Trust Ser 1 TR UNIT 78462F103 786 4,900 SH   OTR   4,900 0 0
Spectranetics Corp. COM 84760C107 6,330 338,851 SH   OTR   318,991 0 19,860
Staar Surgical Co. COM PAR $0.01 852312305 2,552 251,448 SH   OTR   234,498 0 16,950
Streamline Health Solutions, Inc. COM 86323X106 5,124 779,976 SH   OTR   723,467 0 56,509
SunOpta, Inc. COM 8676EP108 10,001 1,317,643 SH   OTR   1,241,708 0 75,935
Superconductor Technologies, Inc. COM PAR $0.001 867931404 1,569 498,227 SH   DFND   498,227 0 0
Superconductor Technologies, Inc. COM PAR $0.001 867931404 1,396 443,273 SH   OTR   443,057 0 216
Synergetics USA, Inc. COM 87160G107 7,645 1,940,342 SH   OTR   1,805,087 0 135,255
TearLab Corp. COM 878193101 10,979 1,033,840 SH   OTR   962,090 0 71,750
Thoratec Corp. COM NEW 885175307 1,331 42,495 SH   OTR   39,740 0 2,755
Triquint Semiconductor Inc. COM 89674K103 139 20,000 SH   DFND   20,000 0 0
Triquint Semiconductor Inc. COM 89674K103 1,245 179,593 SH   OTR   157,912 0 21,681
Uroplasty Inc. COM NEW 917277204 274 132,211 SH   OTR   132,211 0 0
V F Corporation COM 918204108 941 4,875 SH   OTR   4,275 0 600
Vanguard Total Stock TOTAL STK MKT 922908769 256 3,100 SH   OTR   3,100 0 0
Verizon Communications, Inc. COM 92343V104 933 18,531 SH   OTR   16,231 0 2,300
Vertex Pharmaceuticals Inc COM 92532F100 848 10,588 SH   OTR   10,588 0 0
Vitesse Semiconductor Corporation COM NEW 928497304 3,866 1,470,000 SH   DFND   1,470,000 0 0
Vitesse Semiconductor Corporation COM NEW 928497304 6,181 2,350,319 SH   OTR   2,350,319 0 0
Vivus Inc COM 928551100 2,289 181,935 SH   OTR   166,720 0 15,215
Volcano Corporation COM 928645100 395 21,766 SH   OTR   21,766 0 0
Warner Chilcott ADR SHS A G94368100 257 12,905 SH   OTR   12,905 0 0
Wells Fargo & Co. COM 949746101 980 23,748 SH   OTR   20,803 0 2,945