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Property and Equipment:
3 Months Ended
Mar. 31, 2022
Property, Plant and Equipment [Abstract]  
Property and Equipment [Text Block] Property, Plant and Equipment
Property, plant and equipment consists of the following (in thousands): 
As of
 March 31, 2022December 31, 2021
Machinery and equipment$432,649 $321,078 
Land, building and building improvements289,866 243,377 
Molds60,499 60,463 
Computer equipment and software112,661 102,979 
Furniture and fixtures10,646 7,670 
Instruments placed with customers(1)
103,257 97,384 
Construction in progress123,448 72,153 
Total property, plant and equipment, cost1,133,026 905,104 
Accumulated depreciation(458,614)(436,739)
Property, plant and equipment, net$674,412 $468,365 
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(1)    Instruments placed with customers consist of drug-delivery and monitoring systems placed with customers under operating leases.

Depreciation expense was $21.4 million and $16.3 million for the three months ended March 31, 2022 and 2021, respectively.

During the quarter ended March 31, 2022, property, plant and equipment and related depreciation expense increased significantly due to the acquisition of Smiths Medical (see Note 3: Acquisitions).