<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001584348</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000882796</issuerCik>
      <issuerName>BIOCRYST PHARMACEUTICALS INC</issuerName>
      <secFileNumber>000-23186</secFileNumber>
      <issuerAddress>
        <com:street1>4505 EMPEROR BOULEVARD</com:street1>
        <com:street2>SUITE 200</com:street2>
        <com:city>DURHAM</com:city>
        <com:stateOrCountry>NC</com:stateOrCountry>
        <com:zipCode>27703</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>919-859-1302</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Barnes Alane P</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>21210</noOfUnitsSold>
      <aggregateMarketValue>162256.50</aggregateMarketValue>
      <noOfUnitsOutstanding>210543224</noOfUnitsOutstanding>
      <approxSaleDate>12/15/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/14/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>21210</amountOfSecuritiesAcquired>
      <paymentDate>12/14/2025</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Alane Barnes</name>
        <address>
          <com:street1>4505 Emperor Blvd.</com:street1>
          <com:street2>Suite 200</com:street2>
          <com:city>Durham</com:city>
          <com:stateOrCountry>NC</com:stateOrCountry>
          <com:zipCode>27703</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>12/01/2025</saleDate>
      <amountOfSecuritiesSold>91004</amountOfSecuritiesSold>
      <grossProceeds>646506.07</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Alane Barnes</name>
        <address>
          <com:street1>4505 Emperor Blvd.</com:street1>
          <com:street2>Suite 200</com:street2>
          <com:city>Durham</com:city>
          <com:stateOrCountry>NC</com:stateOrCountry>
          <com:zipCode>27703</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>12/02/2025</saleDate>
      <amountOfSecuritiesSold>50906</amountOfSecuritiesSold>
      <grossProceeds>367215.98</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Alane Barnes</name>
        <address>
          <com:street1>4505 Emperor Blvd.</com:street1>
          <com:street2>Suite 200</com:street2>
          <com:city>Durham</com:city>
          <com:stateOrCountry>NC</com:stateOrCountry>
          <com:zipCode>27703</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>12/03/2025</saleDate>
      <amountOfSecuritiesSold>19770</amountOfSecuritiesSold>
      <grossProceeds>151240.50</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>12/15/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>08/13/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Gary Redman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Alane Barnes</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
