Segment Information - Segment Reporting Information by Segment (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Segment Reporting Information [Line Items]
Revenues	$ 450,712	$ 331,412	$ 270,827
Less
Cost of product sales	12,269	4,481	6,408
Research and development	174,638	216,566	253,297
Selling, general and administrative	266,132	213,894	159,371
Royalty	216	180	186
Interest expense	98,516	108,239	99,092
Income tax expense	1,927	310	2,733
Net loss	(88,881)	(226,539)	(247,116)
Reportable Segment
Segment Reporting Information [Line Items]
Revenues	450,712	331,412	270,827
Less
Cost of product sales	12,269	4,481	6,408
Selling, general and administrative	266,132	213,894	159,371
Royalty	216	180	186
Other segment items	641	30,058	1,983
Interest income	(14,746)	(15,777)	(5,127)
Interest expense	98,516	108,239	99,092
Income tax expense	1,927	310	2,733
Net loss	(88,881)	(226,539)	(247,116)
Adjustments and reconciling items	0	0	0
Reportable Segment | Berotralstat
Less
Research and development	45,033	42,835	32,637
Reportable Segment | Factor D Program
Less
Research and development	24,072	94,517	174,234
Reportable Segment | BCX17725
Less
Research and development	32,417	19,133	0
Reportable Segment | Other research, preclinical and development costs
Less
Research and development	$ 73,116	$ 60,081	$ 46,426