Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2024	Dec. 31, 2023
Deferred tax assets:
Net federal and state operating losses	$ 105,865	$ 108,753
Research and development credits	87,287	88,390
Royalty income	117,570	122,391
Stock-based compensation	34,486	26,113
Capitalized R&D	82,476	75,081
Leasing obligations	2,806	3,076
Other	22,693	17,515
Total deferred tax assets	453,183	441,319
Deferred tax liabilities:
Fixed assets	(797)	(678)
Right of use asset	(2,620)	(2,872)
Total deferred tax liabilities	(3,417)	(3,550)
Valuation allowance	(448,740)	(437,098)
Net deferred tax assets	$ 1,026	$ 671