Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Revenues [Abstract]
Revenues	$ 450,712	$ 331,412	$ 270,827
Expenses:
Cost of product sales	12,269	4,481	6,408
Research and development	174,638	216,566	253,297
Selling, general and administrative	266,132	213,894	159,371
Royalty	216	180	186
Total operating expenses	453,255	435,121	419,262
Loss from operations	(2,543)	(103,709)	(148,435)
Interest income	14,746	15,777	5,127
Interest expense	(98,516)	(108,239)	(99,092)
Loss on extinguishment of debt	0	(29,019)	0
Foreign currency losses, net	(641)	(1,039)	(1,983)
Total other expense	(84,411)	(122,520)	(95,948)
Loss before income taxes	(86,954)	(226,229)	(244,383)
Income tax expense	1,927	310	2,733
Net loss	(88,881)	(226,539)	(247,116)
Other comprehensive (loss) income:
Foreign currency translation adjustment	(776)	180	890
Unrealized gain (loss) on available for sale investments	360	1,131	(1,041)
Total other comprehensive (loss) income	(416)	1,311	(151)
Net comprehensive loss	$ (89,297)	$ (225,228)	$ (247,267)
Earnings per share, basic (in usd per share)	$ (0.43)	$ (1.18)	$ (1.33)
Earnings per share, diluted (in usd per share)	$ (0.43)	$ (1.18)	$ (1.33)
Weighted average shares outstanding, basic (in shares)	206,696	192,198	185,908
Weighted average shares outstanding, diluted (in shares)	206,696	192,198	185,908