Condensed Consolidated Statements of Stockholders' Deficit - USD ($) shares in Thousands, $ in Thousands	Total	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive Income	Accumulated Deficit
Common stock, shares outstanding, beginning balance (in shares) at Dec. 31, 2022		187,906
Beginning balance at Dec. 31, 2022	$ (294,597)	$ 1,879	$ 1,158,118	$ 26	$ (1,454,620)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(53,333)				(53,333)
Other comprehensive income (loss)	559			559
Exercise of stock options, net (in shares)		702
Exercise of stock options, net	3,502	$ 7	3,495
Vesting of restricted stock units (in shares)		99
Vesting of restricted stock units	0	$ 1	(1)
Employee stock purchase plan sales, net (in shares)		176
Employee stock purchase plan sales	1,575	$ 2	1,573
Stock-based compensation expense	14,007		14,007
Common stock, shares outstanding, ending balance (in shares) at Mar. 31, 2023		188,883
Ending balance at Mar. 31, 2023	(328,287)	$ 1,889	1,177,192	585	(1,507,953)
Common stock, shares outstanding, beginning balance (in shares) at Dec. 31, 2022		187,906
Beginning balance at Dec. 31, 2022	(294,597)	$ 1,879	1,158,118	26	(1,454,620)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	$ (128,659)
Employee stock purchase plan sales, net (in shares)	176
Common stock, shares outstanding, ending balance (in shares) at Jun. 30, 2023		189,491
Ending balance at Jun. 30, 2023	$ (388,713)	$ 1,895	1,191,981	690	(1,583,279)
Common stock, shares outstanding, beginning balance (in shares) at Mar. 31, 2023		188,883
Beginning balance at Mar. 31, 2023	(328,287)	$ 1,889	1,177,192	585	(1,507,953)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(75,326)				(75,326)
Other comprehensive income (loss)	105			105
Exercise of stock options, net (in shares)		401
Exercise of stock options, net	1,748	$ 4	1,744
Vesting of restricted stock units (in shares)		184
Vesting of restricted stock units	0	$ 2	(2)
Issuance of shares to directors in lieu of cash retainer (in shares)		23
Issuance of shares to directors in lieu of cash retainer	206		206
Stock-based compensation expense	12,841		12,841
Common stock, shares outstanding, ending balance (in shares) at Jun. 30, 2023		189,491
Ending balance at Jun. 30, 2023	$ (388,713)	$ 1,895	1,191,981	690	(1,583,279)
Common stock, shares outstanding, beginning balance (in shares) at Dec. 31, 2023	205,771	205,771
Beginning balance at Dec. 31, 2023	$ (455,528)	$ 2,058	1,222,236	1,337	(1,681,159)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(35,379)				(35,379)
Other comprehensive income (loss)	(566)			(566)
Exercise of stock options, net (in shares)		176
Exercise of stock options, net	552	$ 2	550
Vesting of restricted stock units (in shares)		155
Vesting of restricted stock units	0	$ 1	(1)
Shares withheld for taxes for vesting of restricted stock units (in shares)		(8)
Shares withheld for taxes for vesting of restricted stock units	(38)		(38)
Employee stock purchase plan sales, net (in shares)		251
Employee stock purchase plan sales	1,129	$ 2	1,127
Issuance of shares to directors in lieu of cash retainer (in shares)		2
Issuance of shares to directors in lieu of cash retainer	11		11
Stock-based compensation expense	13,652		13,652
Common stock, shares outstanding, ending balance (in shares) at Mar. 31, 2024		206,347
Ending balance at Mar. 31, 2024	$ (476,167)	$ 2,063	1,237,537	771	(1,716,538)
Common stock, shares outstanding, beginning balance (in shares) at Dec. 31, 2023	205,771	205,771
Beginning balance at Dec. 31, 2023	$ (455,528)	$ 2,058	1,222,236	1,337	(1,681,159)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	$ (48,053)
Employee stock purchase plan sales, net (in shares)	251
Common stock, shares outstanding, ending balance (in shares) at Jun. 30, 2024	206,629	206,629
Ending balance at Jun. 30, 2024	$ (475,606)	$ 2,066	1,250,983	557	(1,729,212)
Common stock, shares outstanding, beginning balance (in shares) at Mar. 31, 2024		206,347
Beginning balance at Mar. 31, 2024	(476,167)	$ 2,063	1,237,537	771	(1,716,538)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(12,674)				(12,674)
Other comprehensive income (loss)	(214)			(214)
Exercise of stock options, net (in shares)		80
Exercise of stock options, net	264	$ 1	263
Vesting of restricted stock units (in shares)		200
Vesting of restricted stock units	0	$ 2	(2)
Issuance of shares to directors in lieu of cash retainer (in shares)		2
Issuance of shares to directors in lieu of cash retainer	12		12
Stock-based compensation expense	$ 13,173		13,173
Common stock, shares outstanding, ending balance (in shares) at Jun. 30, 2024	206,629	206,629
Ending balance at Jun. 30, 2024	$ (475,606)	$ 2,066	$ 1,250,983	$ 557	$ (1,729,212)