Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Revenues [Abstract]
Revenues	$ 331,412	$ 270,827	$ 157,170
Expenses:
Cost of product sales	4,481	6,408	7,229
Research and development	216,566	253,297	208,808
Selling, general and administrative	213,894	159,371	118,818
Royalty	180	186	35
Total operating expenses	435,121	419,262	334,890
Loss from operations	(103,709)	(148,435)	(177,720)
Interest and other income	15,777	5,127	62
Interest expense	(108,239)	(99,092)	(59,294)
(Loss) gain on extinguishment of debt	(29,019)	0	55,838
Foreign currency losses, net	(1,039)	(1,983)	(695)
Loss before income taxes	(226,229)	(244,383)	(181,809)
Income tax expense	310	2,733	2,253
Net loss	(226,539)	(247,116)	(184,062)
Foreign currency translation adjustment	180	890	189
Unrealized gain (loss) on available for sale investments	1,131	(1,041)	(15)
Net comprehensive loss	$ (225,228)	$ (247,267)	$ (183,888)
Earnings per share, basic (in usd per share)	$ (1.18)	$ (1.33)	$ (1.03)
Earnings per share, diluted (in usd per share)	$ (1.18)	$ (1.33)	$ (1.03)
Weighted average shares outstanding, basic (in shares)	192,198	185,908	179,117
Weighted average shares outstanding, diluted (in shares)	192,198	185,908	179,117