Income Taxes (Tables)

12 Months Ended

Dec. 31, 2023

Income Tax Disclosure [Abstract]

Schedule Of Loss Before Provision For Income Taxes

The components of loss before provision for income taxes were as follows (in thousands):

	Years Ended December 31,
	2023		2022		2021
Domestic	$	(206,674)	$	(225,127)	$	(159,632)
Foreign	(19,555)		(19,256)		(22,177)
Loss before provision for income taxes	$	(226,229)	$	(244,383)	$	(181,809)

Schedule of Components of Income Tax (Benefit) Expense

The components of the (benefit) expense for income taxes were as follows (in thousands):

	Years Ended December 31,
	2023		2022		2021
Current expense (benefit) provision:
U.S. Federal and state	$	(45)	$	2,430	$	2,179
Foreign	1,037		292		233
Total current expense provision	992		2,722		2,412
Deferred expense (benefit) provision:
U.S. Federal and state	(120)		11		(159)
Foreign	(562)		—		—
Total deferred expense provision	(682)		11		(159)
Total expense provision	$	310	$	2,733	$	2,253

Summary Of The Differences Between The Company's Effective Tax Rate And Statutory Tax Rate

The differences between the Company’s effective tax rate and the statutory tax rate in 2023, 2022, and 2021 were as follows (in thousands):

	Years Ended December 31,
	2023		2022		2021
Income tax benefit at federal statutory rate (21% for 2023, 2022 and 2021)	$	(47,328)	$	(51,321)	$	(38,175)
State and local income taxes net of federal tax benefit	(3,477)		(1,816)		(2,288)
Permanent items	3,015		(1,608)		(1,343)
Expiration of attribute carryforwards	—		—		(1,057)
Research and development tax credits	(3,301)		(9,793)		(5,994)
Foreign rate differential	2,255		1,862		1,940
Other	1,656		(5,485)		1,216
Change in valuation allowance	47,490		70,894		47,954
Income tax expense	$	310	$	2,733	$	2,253

Schedule Of Unrecognized Tax Benefits

A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows (in thousands):

	2023		2022
Balance at January 1,	$	13,844	$	9,729
Additions to current period tax positions	825		4,115
Reductions to prior period tax provisions	(307)		—
Balance at December 31,	$	14,362	$	13,844

Schedule Of Deferred Tax Assets And Liabilities

Significant components of the Company’s deferred tax assets and liabilities are as follows (in thousands):

	December 31,
	2023		2022
Deferred tax assets:
Net federal and state operating losses	$	108,753	$	101,600
Research and development credits	88,390		86,321
Royalty income	122,391		115,554
Stock-based compensation	26,113		19,374
Capitalized R&D	75,081		62,794
Leasing obligations	3,076		1,842
Other	17,515		4,354
Total deferred tax assets	441,319		391,839
Deferred tax liabilities:
Fixed assets	(678)		(717)
Right of use asset	(2,872)		(1,525)
Total deferred tax liabilities	(3,550)		(2,242)
Valuation allowance	(437,098)		(389,608)
Net deferred tax assets (liabilities)	$	671	$	(11)