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Cover Page - USD ($)
 12 Months Ended
Dec. 31, 2023
Feb. 23, 2024
Jun. 30, 2023
Cover [Abstract]      
Document Type 10-K    
Document Annual Report true    
Document Period End Date Dec. 31, 2023    
Current Fiscal Year End Date --12-31    
Document Transition Report false    
Entity File Number 000-23186    
Entity Registrant Name BIOCRYST PHARMACEUTICALS, INC.    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 62-1413174    
Entity Address, Address Line One 4505 Emperor Blvd., Suite 200    
Entity Address, City or Town Durham    
Entity Address, State or Province NC    
Entity Address, Postal Zip Code 27703    
City Area Code 919    
Local Phone Number 859-1302    
Title of 12(b) Security Common Stock, $0.01 par value    
Trading Symbol BCRX    
Security Exchange Name NASDAQ    
Entity Well-known Seasoned Issuer Yes    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Large Accelerated Filer    
Entity Small Business false    
Entity Emerging Growth Company false    
ICFR Auditor Attestation Flag true    
Document Financial Statement Error Correction [Flag] false    
Entity Shell Company false    
Entity Public Float     $ 1,322,900,797
Entity Common Stock, Shares Outstanding   206,149,929  
Documents Incorporated by Reference
DOCUMENTS INCORPORATED BY REFERENCE
Portions of the registrant’s definitive proxy statement to be filed in connection with the solicitation of proxies for its 2024 annual meeting of stockholders are incorporated by reference into Items 10, 11, 12, 13, and 14 under Part III hereof.
    
Entity Central Index Key 0000882796    
Document Fiscal Year Focus 2023    
Document Fiscal Period Focus FY    
Amendment Flag false