Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Revenues
Revenues	$ 68,778	$ 49,923
Expenses:
Cost of product sales	931	236
Research and development	48,388	65,360
Selling, general and administrative	47,867	34,282
Royalty	7	2
Total operating expenses	97,193	99,880
Loss from operations	(28,415)	(49,957)
Interest and other income	3,378	54
Interest expense	(27,396)	(23,837)
Foreign currency losses, net	(229)	(177)
Loss before income taxes	(52,662)	(73,917)
Income tax expense	671	279
Net loss	(53,333)	(74,196)
Foreign currency translation adjustment	59	78
Unrealized gain (loss) on available for sale investments	500	(69)
Comprehensive loss	$ (52,774)	$ (74,187)
Basic net loss per common share (in usd per share)	$ (0.28)	$ (0.40)
Diluted net loss per common share (in usd per share)	$ (0.28)	$ (0.40)
Weighted average shares outstanding, basic (in shares)	188,509	184,898
Weighted average shares outstanding, diluted (in shares)	188,509	184,898