Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Cash flows from operating activities:
Net loss	$ (247,116)	$ (184,062)	$ (182,814)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,437	777	748
Inventory obsolescence expense	932	0	0
Stock-based compensation expense	44,701	34,640	14,794
Non-cash interest expense on royalty financing obligations and secured term loan and amortization of debt issuance costs	98,918	54,204	3,325
Amortization of premium/discount on investments	(1,777)	(2)	121
Change in fair value of foreign currency derivative	0	0	632
(Gain) loss on extinguishment of debt	0	(55,838)	1,211
Changes in operating assets and liabilities:
Receivables	(21,470)	(20,817)	13,903
Inventory	(12,423)	(8,767)	(7,039)
Prepaid expenses and other assets	(2,583)	(7,155)	(2,140)
Accounts payable and accrued expenses	(22,360)	39,412	17,355
Interest payable	0	4,168	6,766
Deferred revenue	(109)	1,283	(1,970)
Net cash used in operating activities	(161,850)	(142,157)	(135,108)
Cash flows from investing activities:
Acquisition of property and equipment	(1,351)	(2,385)	(514)
Purchases of investments	(244,283)	(10,012)	(49,818)
Sales and maturities of investments	117,396	28,201	43,476
Net cash (used in) provided by investing activities	(128,238)	15,804	(6,856)
Cash flows from financing activities:
Sale of common stock, net	0	50,000	93,279
Sale of pre-funded warrants	0	0	14,817
Net proceeds from common stock issued under stock-based compensation plans	14,955	15,794	2,446
Proceeds from additional credit facility	73,072	0	0
Payment of senior credit facility	0	0	(52,420)
Net proceeds from secured term loan	0	0	119,867
Net proceeds from royalty financing obligations	0	293,874	122,600
Net cash provided by financing activities	88,027	359,668	300,589
Effects of exchange rates on cash, cash equivalents and restricted cash	566	71	0
(Decrease) increase in cash, cash equivalents and restricted cash	(201,495)	233,386	158,625
Cash, cash equivalents and restricted cash at beginning of year	507,734	274,348	115,723
Cash, cash equivalents and restricted cash at end of year	$ 306,239	$ 507,734	$ 274,348