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Employee Service Share-Based Compensation Nonvested Awards Compensation Cost Expected To Be Recognized Year Four

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Employee Service Share-Based Compensation Nonvested Awards Compensation Cost Expected To Be Recognized Year Three

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Employee Service Share-Based Compensation Nonvested Awards Compensation Cost Expected To Be Recognized Year Two

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Percentage Of Common Stock Shares Beginning

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Percentage Of Common Stock Shares Ending

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Percentage Of Salary To Purchase Common Stock Maximum

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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

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Weighted average purchase price of capital shares purchased through an employee stock ownership plan.

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Period over which grantee's right to exercise award under share-based payment arrangement is no longer contingent on satisfaction of service or performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, combination of market, performance or service condition.

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The weighted average fair value at grant date for nonvested equity-based awards issued during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The highest quantity of shares an employee can purchase under the plan per period.

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Net number of non-option equity instruments granted to participants.

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Number of shares authorized for issuance under share-based payment arrangement.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares.

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Gross number of share options (or share units) granted during the period.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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Number of fully vested and expected to vest options outstanding that can be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Percentage of vesting of award under share-based payment arrangement.

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Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for fully vested and expected to vest options outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Fair value of options vested. Excludes equity instruments other than options, for example, but not limited to, share units, stock appreciation rights, restricted stock.

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Number of shares issued during the period as a result of an employee stock purchase plan.

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Note 12 - Stock-Based Compensation Textual (Details) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended				12 Months Ended
	Jan. 31, 2022	Dec. 31, 2019	Dec. 31, 2014	Aug. 31, 2013	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Total stock-based compensation expense					$ 44,701	$ 34,640	$ 14,794
Options, grants in period, gross (in shares)					7,603,000
Options, grants in period, weighted average grant date fair value (in dollars per share)					$ 8.03
Exercise of stock options, net (in shares)					3,044,000
Total unrecognized compensation cost					$ 148,700
Compensation cost expected to be recognized next year					50,713
Compensation cost expected to be recognized year two					46,329
Compensation cost expected to be recognized year three					34,537
Compensation cost expected to be recognized year four					$ 17,121
Employee stock purchase plan sales, net (in shares)					260,000	321,000	246,000
Share-based Payment Arrangement, Option \| Non-employee Directors
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period (year)					1 year
Incentive Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Total stock-based compensation expense					$ 36,716	$ 27,062	$ 12,938
Options, grants in period, weighted average grant date fair value (in dollars per share)					$ 7.57	$ 7.93	$ 5.48
Options, exercises in period, intrinsic value					$ 21,150	$ 25,484	$ 1,562
Exercise of stock options, net (in shares)					2,257,000	2,705,000	510,000
Number of shares available for grant (in shares)		968,000			4,206,000	3,651,000	4,592,000
Incentive Plan \| Share-based Payment Arrangement, Option \| Maximum
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Options, exercisable, weighted average remaining contractual term (year)					10 years
Incentive Plan \| Share-based Payment Arrangement, Option \| Vest 25% Each Year Until Fully Vested
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting rights, percentage					25.00%
Award vesting period (year)					4 years
Incentive Plan \| Share-based Payment Arrangement, Option \| Thirty-six Equal Monthly Installments \| Non-employee Directors
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period (year)					3 years
Incentive Plan \| Share-based Payment Arrangement, Option \| Thirty-six Equal Monthly Installments \| Non-employee Directors
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period (year)	3 years
Incentive Plan \| Performance Shares \| August 2013
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Total stock-based compensation expense							$ 1,768
Incentive Plan \| Performance Shares \| December 2019
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Total stock-based compensation expense							684
Incentive Plan \| Performance Shares \| Vest Upon Successful Completion of Specific Development Milestones
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting rights, percentage		100.00%	85.00%	100.00%
Options, grants in period, gross (in shares)		315,000	1,250,000	1,032,000
Incentive Plan \| Restricted Stock Units (RSUs)
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Restricted stock units, grants in period, weighted average grant date fair value (in dollars per share)					$ 11.20	$ 11.36
Incentive Plan \| Performance-based Restricted Stock Units \| Vest 25% Each Year Until Fully Vested
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Total stock-based compensation expense	$ 158
Award vesting rights, percentage	25.00%
Incentive Plan \| Performance-based Restricted Stock Units \| Vest Upon Successful Completion of Specific Development Milestones
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Issued performance-based RSU award (in shares)	221,000
Incentive Plan \| Performance-based Restricted Stock Units \| Share-Based Payment Arrangement, Tranche One
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting rights, percentage	50.00%
Inducement Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Total stock-based compensation expense					$ 6,550	$ 6,055	$ 1,494
Award vesting period (year)					4 years
Options, grants in period, weighted average grant date fair value (in dollars per share)					$ 9.54	$ 9.65	$ 2.73
Expiration period (year)					10 years
Options, exercises in period, intrinsic value					$ 3,710	$ 6,700
Exercise of stock options, net (in shares)					358,000	592,000	0
Number of shares available for grant (in shares)		171,000			947,000	900,000	229,000
Inducement Plan \| Vest 25% Each Year Until Fully Vested
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting rights, percentage					25.00%
Inducement Plan \| Share-based Payment Arrangement, Option
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Expected Dividend Yield					0.00%
Inducement Plan \| Restricted Stock Units (RSUs)
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Options, grants in period, gross (in shares)						0	0
Options, grants in period, weighted average grant date fair value (in dollars per share)					$ 13.21
Employee Stock Purchase Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Total stock-based compensation expense					$ 1,435	$ 1,523	$ 362
Restricted stock units, grants in period, weighted average grant date fair value (in dollars per share)					$ 6.02	$ 2.80	$ 1.47
Number of shares authorized (in shares)					7,975,000
Number of shares available for grant (in shares)					5,792,000
Percentage of salary to purchase common stock, maximum					15.00%
Percentage of common stock shares, beginning					85.00%
Percentage of common stock shares, ending					85.00%
Maximum number of shares per employee (in shares)					3,000
Maximum number of shares per employee, amount					$ 25
Weighted average purchase price of shares purchased (in dollars per share)					$ 11.03	$ 6.20	$ 2.56
Incentive Plan and Inducement Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Options, exercisable, weighted average remaining contractual term (year)					5 years 9 months 18 days
Expected Dividend Yield					0.00%	0.00%	0.00%
Options, aggregate intrinsic value					$ 83,783
Options, vested in period, fair value					$ 33,575	$ 23,395	$ 18,739
Number of stock option awards vested and expected to vest (in shares)					32,837
Weighted average exercise price of stock option awards vested and expected to vest (in dollars per share)					$ 8.52
Stock option awards vested and expected to vest, weighted average remaining contractual life (year)					7 years 2 months 12 days