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Note 12 - Stock-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]  
Stock-Based Compensation Allocation Total stock-based compensation was allocated as follows:
Years Ended December 31,
202220212020
Research and development$24,936 $20,179 $10,222 
Selling, general and administrative19,765 14,461 4,572 
Total stock-based compensation expense$44,701 $34,640 $14,794 
Stock Plan Activities
Related activity under the Incentive Plan is as follows:
Awards
Available		Options
Outstanding		Weighted
Average
Exercise
Price
Balance at December 31, 2019968 21,050 $5.96 
Plan amendment8,000 — — 
Restricted stock unit awards granted(31)— — 
Stock option awards granted(7,469)7,469 8.06 
Stock option awards exercised— (510)3.56 
Stock option awards cancelled3,124 (3,124)6.93 
Balance at December 31, 20204,592 24,885 $6.52 
Plan amendment7,500 — — 
Restricted stock unit awards granted(1,936)— — 
Stock option awards granted(6,753)6,753 11.57 
Stock option awards exercised— (2,705)4.36 
Stock option awards cancelled248 (248)7.62 
Balance at December 31, 20213,651 28,685 $7.90 
Plan amendment8,000 — — 
Restricted stock unit awards granted(2,948)— — 
Restricted stock unit awards cancelled254 — — 
Stock option awards granted(5,784)5,784 10.70 
Stock option awards exercised— (2,257)5.00 
Stock option awards cancelled1,033 (1,033)10.02 
Balance at December 31, 20224,206 31,179 $8.56 
Related activity under the Inducement Plan is as follows:
Awards
Available		Options
Outstanding		Weighted
Average
Exercise
Price
Balance at December 31, 2019171 1,329 $3.60 
Plan amendment2,900 — — 
Stock option awards granted(3,002)3,002 4.02 
Stock option awards cancelled160 (160)4.15 
Balance at December 31, 2020229 4,171 $3.88 
Plan amendment1,500 — — 
Stock option awards granted(1,003)1,003 13.91 
Stock option awards exercised— (592)3.63 
Stock option awards cancelled174 (174)3.67 
Balance at December 31, 2021900 4,408 $6.20 
Plan amendment1,926 — — 
Restricted stock unit awards granted(603)— — 
Restricted stock unit awards cancelled15 — — 
Stock option awards granted(1,819)1,819 13.54 
Stock option awards exercised— (358)3.45 
Stock option awards cancelled528 (528)7.44 
Balance at December 31, 2022947 5,341 $8.80 
Weighted Average Assumptions for Stock Option Awards Granted to Employees and Directors Under the Plans
202220212020
Expected Life5.55.55.5
Expected Volatility84 %84 %84 %
Expected Dividend Yield0.0 %0.0 %0.0 %
Risk-Free Interest Rate3.5 %1.1 %0.4 %
Number of Stock Option Awards Exercisable and their Weighted Average Exercise Price
The following table summarizes, at December 31, 2022, by price range: (1) for stock option awards outstanding under the Incentive and Inducement Plans, the number of stock option awards outstanding, their weighted average remaining life and their weighted average exercise price; and (2) for stock option awards exercisable under the Incentive and Inducement Plans, the number of stock option awards exercisable and their weighted average exercise price:
OutstandingExercisable
RangeNumberWeighted
Average
Remaining
Life		Weighted
Average
Exercise
Price		NumberWeighted
Average
Exercise
Price
$0 to31,1456.3$2.65 777$2.66 
3 to68,6535.74.23 7,1834.32 
6 to99,7047.27.90 6,3327.70 
9 to1213,3908.310.89 3,28711.01 
12 to152,1897.513.06 92712.80 
15 to181,4398.416.02 32215.89 
$0 to1836,5207.3$8.59 18,828$7.17 
Changes in the Number and Weighted-Average Grant-Date Fair Value
The following table summarizes the changes in the number and weighted-average grant-date fair value of non-vested stock option awards during 2022:
Non-Vested Stock Option AwardsWeighted Average Grant-Date Fair Value
Balance December 31, 202117,532 $6.06 
Stock option awards granted7,603 8.03 
Stock option awards vested(5,908)5.68 
Stock option awards forfeited(1,535)6.24 
Balance December 31, 202217,692 $7.02