Consolidated Statements of Stockholders' Deficit - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Income	Accumulated Deficit
Balance at Dec. 31, 2020	$ (19,262)	$ 1,769	$ 1,002,408	$ 3	$ (1,023,442)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(64,284)				(64,284)
Other comprehensive income (loss)	179			179
Employee stock purchase plan sales, net	723	2	721
Exercise of stock options, net	2,177	6	2,171
Stock-based compensation expense	5,479		5,479
Balance at Mar. 31, 2021	(74,988)	1,777	1,010,779	182	(1,087,726)
Balance at Dec. 31, 2020	(19,262)	1,769	1,002,408	3	(1,023,442)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(166,283)
Balance at Sep. 30, 2021	(147,044)	1,798	1,040,769	114	(1,189,725)
Balance at Mar. 31, 2021	(74,988)	1,777	1,010,779	182	(1,087,726)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(43,198)				(43,198)
Other comprehensive income (loss)	(95)			(95)
Exercise of stock options, net	4,574	10	4,564
Stock-based compensation expense	7,632		7,632
Balance at Jun. 30, 2021	(106,075)	1,787	1,022,975	87	(1,130,924)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(58,801)				(58,801)
Other comprehensive income (loss)	27			27
Employee stock purchase plan sales, net	1,241	1	1,240
Exercise of stock options, net	3,535	10	3,525
Stock-based compensation expense	13,029		13,029
Balance at Sep. 30, 2021	(147,044)	1,798	1,040,769	114	(1,189,725)
Balance at Dec. 31, 2021	(106,986)	1,843	1,098,498	177	(1,207,504)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(74,196)				(74,196)
Other comprehensive income (loss)	9			9
Employee stock purchase plan sales, net	1,504	1	1,503
Exercise of stock options, net	5,853	12	5,841
Stock-based compensation expense	9,601		9,601
Balance at Mar. 31, 2022	(164,215)	1,856	1,115,443	186	(1,281,700)
Balance at Dec. 31, 2021	(106,986)	1,843	1,098,498	177	(1,207,504)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(175,575)
Balance at Sep. 30, 2022	(242,659)	1,864	1,138,654	(98)	(1,383,079)
Balance at Mar. 31, 2022	(164,215)	1,856	1,115,443	186	(1,281,700)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(58,859)				(58,859)
Other comprehensive income (loss)	(171)			(171)
Exercise of warrants	3	3
Exercise of stock options, net	145		145
Stock-based compensation expense	9,865		9,865
Balance at Jun. 30, 2022	(213,232)	1,859	1,125,453	15	(1,340,559)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(42,520)				(42,520)
Other comprehensive income (loss)	(113)			(113)
Employee stock purchase plan sales, net	1,357	1	1,356
Exercise of stock options, net	1,896	4	1,892
Stock-based compensation expense	9,953		9,953
Balance at Sep. 30, 2022	$ (242,659)	$ 1,864	$ 1,138,654	$ (98)	$ (1,383,079)