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Stock-based Compensation (Details Textual)
$ / shares in Units, shares in Thousands, $ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Jan. 31, 2022
shares
Dec. 31, 2014
shares
Mar. 31, 2022
shares
Mar. 31, 2021
shares
Jun. 30, 2022
USD ($)
plan
$ / shares
shares
Jun. 30, 2021
USD ($)
$ / shares
shares
Dec. 31, 2021
shares
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Number of plans | plan         3    
Share-based payment arrangement, expense         $ 19,468 $ 13,111  
Total unrecognized compensation expense related to non-vested stock options and RSU awards         104,406    
Compensation cost expected to be recognized for remainder of fiscal year         20,395    
Compensation cost expected to be recognized next year         34,794    
Compensation cost expected to be recognized year two         30,343    
Compensation cost expected to be recognized year three         18,002    
Compensation cost expected to be recognized year four         $ 872    
Employee stock purchase plan sales, net (in shares) | shares     115 193 115 193  
Share-Based Payment Arrangement, Option | Non-employee Directors              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting period (in years)         1 year    
Incentive Plan              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Share-based payment arrangement, expense         $ 15,867 $ 11,073  
Number of common stock shares available for purchase (in shares) | shares         10,736   3,651
Incentive Plan | Share-Based Payment Arrangement, Option              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Weighted average grant date fair value stock option awards (in dollars per share) | $ / shares         $ 7.78 $ 7.84  
Incentive Plan | Share-Based Payment Arrangement, Option | Maximum              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Stock option awards remaining contractual term (in years)         10 years    
Incentive Plan | Share-Based Payment Arrangement, Option | Vest 25% Each Year Until Fully Vested              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting rights, percentage         25.00%    
Award vesting period (in years)         4 years    
Incentive Plan | Share-Based Payment Arrangement, Option | Thirty-six Equal Monthly Installments | Non-employee Directors              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting period (in years)         3 years    
Incentive Plan | Performance Shares | Vest Upon Successful Completion of Specific Development Milestones              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting rights, percentage   85.00%          
Performance-based stock options issued in period (in shares) | shares   1,250          
Incentive Plan | Performance-based Restricted Stock Units              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting period (in years) 3 years            
Incentive Plan | Performance-based Restricted Stock Units | Vest 25% Each Year Until Fully Vested              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting rights, percentage 25.00%            
Incentive Plan | Performance-based Restricted Stock Units | Vest Upon Successful Completion of Specific Development Milestones              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Performance-based restricted stock unit awards issued (in shares) | shares 221            
Incentive Plan | Performance-based Restricted Stock Units | Share-Based Payment Arrangement, Tranche One              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting rights, percentage 50.00%            
Incentive Plan | Restricted Stock Units (RSUs)              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Weighted average grant date fair value (in dollars per share) | $ / shares         $ 13.25 $ 10.17  
Inducement Plan              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Share-based payment arrangement, expense         $ 2,965 $ 1,274  
Award vesting period (in years)         4 years    
Weighted average grant date fair value stock option awards (in dollars per share) | $ / shares         $ 10.28 $ 5.86  
Expiration period (in years)         10 years    
Number of common stock shares available for purchase (in shares) | shares         132   900
Inducement Plan | Vest 25% Each Year Until Fully Vested              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting rights, percentage         25.00%    
Inducement Plan | Share-Based Payment Arrangement, Option              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Expected Dividend Yield         0.00%    
Inducement Plan | Restricted Stock Units (RSUs)              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Weighted average grant date fair value (in dollars per share) | $ / shares         $ 13.88    
Employee Stock Purchase Plan              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Share-based payment arrangement, expense         $ 636 $ 764  
Number of shares of common stock authorized to be purchased (in shares) | shares         7,975    
Number of common stock shares available for purchase (in shares) | shares         5,937    
Percentage of salary to purchase common stock, maximum         15.00%    
Percentage of common stock shares, beginning         85.00%    
Percentage of common stock shares, ending         85.00%    
Maximum number of shares per employee (in shares) | shares         3    
Maximum number of shares per employee, amount         $ 25