Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenues
Total revenues	$ 65,532	$ 49,959	$ 115,455	$ 69,018
Expenses
Cost of product sales	246	297	482	6,220
Research and development	61,990	52,873	127,350	95,308
Selling, general and administrative	38,017	26,325	72,299	48,439
Royalty	1	46	3	10
Total operating expenses	100,254	79,541	200,134	149,977
Loss from operations	(34,722)	(29,582)	(84,679)	(80,959)
Interest and other income	609	13	663	39
Interest expense	(24,022)	(13,495)	(47,859)	(26,399)
Foreign currency gains (losses), net	132	(134)	(45)	(163)
Loss before income taxes	(58,003)	(43,198)	(131,920)	(107,482)
Income tax expense	856	0	1,135	0
Net loss	(58,859)	(43,198)	(133,055)	(107,482)
Foreign currency translation adjustment	104	(92)	182	86
Unrealized loss on available for sale investments	(275)	(3)	(344)	(2)
Comprehensive loss	$ (59,030)	$ (43,293)	$ (133,217)	$ (107,398)
Basic net loss per common share (in usd per share)	$ (0.32)	$ (0.24)	$ (0.72)	$ (0.60)
Diluted net loss per common share (in usd per share)	$ (0.32)	$ (0.24)	$ (0.72)	$ (0.60)
Weighted average shares outstanding, basic (in shares)	185,605	178,127	185,253	177,737
Weighted average shares outstanding, diluted (in shares)	185,605	178,127	185,253	177,737
Product sales, net
Revenues
Total revenues	$ 64,888	$ 33,430	$ 114,434	$ 51,301
Royalty revenue
Revenues
Total revenues	540	128	887	(769)
Milestone revenue
Revenues
Total revenues	0	15,000	0	15,000
Collaborative and other research and development
Revenues
Total revenues	$ 104	$ 1,401	$ 134	$ 3,486