Note 4 - Trade Receivables (Details Textual) - Trade Accounts Receivable [Member] - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Accounts Receivable, after Allowance for Credit Loss, Total	$ 0	$ 0
ORLADEYO [Member]
Accounts Receivable, after Allowance for Credit Loss, Total	27,384	149
RAPIVAB [Member]
Accounts Receivable, after Allowance for Credit Loss, Total	49	254
Green Cross Corporation [Member]
Accounts Receivable, after Allowance for Credit Loss, Total	$ 701	$ 0

Amount, after allowance for credit loss, of right to consideration from customer for product sold and service rendered in normal course of business.

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 954
-SubTopic 310
-Section 45
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=123366838&loc=d3e3073-115593

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02(3))
-URI http://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 944
-SubTopic 210
-Section S99
-Paragraph 1
-Subparagraph (SX 210.7-03(5))
-URI http://asc.fasb.org/extlink&oid=120400017&loc=d3e572229-122910

Name:	us-gaap_AccountsReceivableNet
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant