Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Net loss	$ (64,284)	$ (37,599)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	178	218
Stock-based compensation expense	5,479	2,754
Non-cash interest expense on royalty financing obligation	7,536	0
Non-cash paid in-kind interest on secured term loan	3,549	0
Amortization of debt issuance costs	(58)	341
Amortization of premium/discount on investments	14	4
Change in fair value of foreign currency derivative	0	20
Changes in operating assets and liabilities:
Receivables	(261)	16,504
Inventory	1,927	0
Prepaid expenses and other assets	(9,850)	(847)
Accounts payable, accrued expenses and other liabilities	(7,373)	(5,100)
Interest payable	1,877	1,477
Deferred revenue	255	(1,053)
Net cash used in operating activities	(61,011)	(23,281)
Investing activities
Acquisitions of property and equipment	(99)	(116)
Sales and maturities of investments	14,771	10,840
Realized gain on investments	1	0
Net cash provided by investing activities	14,673	10,724
Financing activities
Net proceeds from common stock issued under stock-based compensation plans	2,900	266
Net cash provided by financing activities	2,900	266
Decrease in cash, cash equivalents and restricted cash	(43,438)	(12,291)
Cash, cash equivalents and restricted cash at beginning of period	274,348	115,723
Cash, cash equivalents and restricted cash at end of period	$ 230,910	$ 103,432