Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Revenues:
Revenues	$ 19,059	$ 4,823
Expenses
Cost of product sales	5,923	0
Research and development	42,435	29,867
Selling, general and administrative	22,114	15,865
Royalty	(36)	69
Total operating expenses	70,436	45,801
Loss from operations	(51,377)	(40,978)
Interest and other income	26	6,446
Interest expense	(12,904)	(3,047)
Loss on foreign currency	(29)	(20)
Net loss	(64,284)	(37,599)
Foreign currency translation adjustment	178	0
Unrealized gain (loss) on available for sale investments	1	(25)
Comprehensive loss	$ (64,105)	$ (37,624)
Basic and diluted net loss per common share (in dollars per share)	$ (0.36)	$ (0.24)
Weighted average shares outstanding (in shares)	177,343	154,156
Product [Member]
Revenues:
Revenues	$ 17,871	$ 218
Royalty [Member]
Revenues:
Revenues	(897)	1,945
Collaborative and Other Research and Development [Member]
Revenues:
Revenues	$ 2,085	$ 2,660