The amount of amortization of debt financing costs and original issue discounts.

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Average maturity for portfolio investments during the period.

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Average maturity period of high quality marketable securities.

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Represents long term investment maturity minimum.

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Represents maturity period of high quality marketable securities.

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Maturity period of short term investment.

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Amount, after allowance for credit loss, of right to consideration from customer for product sold and service rendered in normal course of business.

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Amount charged to advertising expense for the period, which are expenses incurred with the objective of increasing revenue for a specified brand, product or product line.

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Amount of allowance for credit loss on accounts receivable.

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Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.

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Amount of decrease in the fair value of derivatives recognized in the income statement.

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Amount of the cost of borrowed funds accounted for as interest expense for debt.

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Amount of borrowing capacity currently available under the credit facility (current borrowing capacity less the amount of borrowings outstanding).

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Useful life of long lived, physical assets used in the normal conduct of business and not intended for resale, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Examples include, but not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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Amount before tax of reclassification adjustments of other comprehensive income (loss).

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Amount of cash and cash equivalents restricted as to withdrawal or usage, classified as current. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.

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Note 1 - Significant Accounting Policies (Details Textual) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020	Dec. 31, 2020
Restricted Cash and Cash Equivalents, Current, Total	$ 4,008		$ 2,221
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax	1	$ 0
Advertising Expense	1,404
Interest Expense, Debt, Total	12,904	3,047
Amortization of Debt Financing Costs and Original Issue Discounts	$ (58)	$ 341
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares)	23,741	12,196
Foreign Exchange Contract [Member] \| Not Designated as Hedging Instrument [Member]
Derivative, Loss on Derivative		$ 20
Computer Equipment [Member]
Property, Plant and Equipment, Useful Life (Year)	3 years
Laboratory Equipment, Office Equipment and Software [Member]
Property, Plant and Equipment, Useful Life (Year)	5 years
Furniture and Fixtures [Member]
Property, Plant and Equipment, Useful Life (Year)	7 years
Trade Accounts Receivable [Member]
Accounts Receivable, after Allowance for Credit Loss, Total	$ 0		0
Accounts Receivable, Allowance for Credit Loss, Ending Balance			0
Collaboration Receivables [Member]
Accounts Receivable, Allowance for Credit Loss, Ending Balance			0
ORLADEYO [Member] \| Trade Accounts Receivable [Member]
Accounts Receivable, after Allowance for Credit Loss, Total	9,882		149
RAPIVAB [Member] \| Trade Accounts Receivable [Member]
Accounts Receivable, after Allowance for Credit Loss, Total	$ 0		254
Maximum [Member]
Maturity Period of High Quality Marketable Securities (Year)	3 years
Average Maturity Period of High Quality Marketable Securities (Month)	18 months
Maturity Period of Short Term Investment (Month)	12 months
Average Maturity for Portfolio Investments (Month)	18 months
Minimum [Member]
Long-term Investment Maturity, Minimum (Month)	12 months
Royalty Receivable [Member]
Restricted Cash and Cash Equivalents, Current, Total	$ 2,587		796
Collateral for Credit [Member]
Restricted Cash and Cash Equivalents, Current, Total	1,421		$ 1,425
Senior Credit Facility [Member] \| MidCap Financial Services, LLC [Member]
Line of Credit Facility, Remaining Borrowing Capacity	$ 75,000
Interest Expense, Debt, Total		$ 1,454