Note 1 - Significant Accounting Policies and Concentrations of Risk (Details Textual) - USD ($)	1 Months Ended	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Restricted Cash and Cash Equivalents, Current, Total	$ 2,221,000	$ 2,221,000	$ 1,551,000
Inventory, Raw Materials, Gross, Total	206,000	206,000
Inventory, Work in Process, Gross	2,555,000	2,555,000
Inventory, Finished Goods, Gross, Total	4,548,000	4,548,000	276,000
Inventory Valuation Reserves, Ending Balance	270,000	270,000	276,000
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax		1,000	0
Advertising Expense		6,567	0	$ 0
Interest Expense, Debt, Total		14,501,000	11,892,000	9,176,000
Amortization of Debt Financing Costs and Original Issue Discounts		$ 1,217,000	$ 1,278,000	$ 885,000
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares)		14,957	2,805	2,274
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member]
Derivative, Loss on Derivative		$ 632,000	$ 347,000	$ 1,049,000
Derivative, Gain on Derivative		$ 662,000	863,000	$ 941,000
Computer Equipment [Member]
Property, Plant and Equipment, Useful Life (Year)		3 years
Laboratory Equipment, Office Equipment and Software [Member]
Property, Plant and Equipment, Useful Life (Year)		5 years
Furniture and Fixtures [Member]
Property, Plant and Equipment, Useful Life (Year)		7 years
Collaboration Receivables [Member]
Accounts Receivable, Allowance for Credit Loss, Ending Balance	0	$ 0	0
Trade Accounts Receivable [Member]
Accounts Receivable, Allowance for Credit Loss, Ending Balance	0	0
Accounts Receivable, after Allowance for Credit Loss, Total			0
Trade Accounts Receivable [Member] | RAPIVAB [Member]
Accounts Receivable, after Allowance for Credit Loss, Total	254,000	254,000
Trade Accounts Receivable [Member] | ORLADEYO [Member]
Accounts Receivable, after Allowance for Credit Loss, Total	149,000	$ 149,000
Maximum [Member]
Maturity Period of High Quality Marketable Securities (Year)		3 years
Average Maturity Period of High Quality Marketable Securities (Month)		18 months
Maturity Period of Short Term Investment (Month)		12 months
Average Maturity for Portfolio Investments (Month)		18 months
Minimum [Member]
Long-term Investment Maturity, Minimum (Month)		12 months
Royalty Receivable [Member]
Restricted Cash and Cash Equivalents, Current, Total	796,000	$ 796,000	134,000
Collateral for Credit [Member]
Restricted Cash and Cash Equivalents, Current, Total	1,425,000	1,425,000	$ 1,417,000
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member]
Line of Credit Facility, Remaining Borrowing Capacity	75,000,000	75,000,000
Write off of Deferred Debt Issuance Cost	$ 1,211,000	$ 1,211,000