Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues:
Revenues	$ 1,454	$ 8,760	$ 17,924	$ 21,296
Expenses
Cost of products sold		1,142		1,142
Research and development	22,006	17,509	61,457	50,038
General and administrative	7,923	3,343	25,024	9,235
Royalty	18	115	401	431
Total operating expenses	29,947	22,109	86,882	60,846
Loss from operations	(28,493)	(13,349)	(68,958)	(39,550)
Interest and other income	611	225	1,566	537
Interest expense	(2,346)	(2,140)	(6,762)	(6,334)
Gain (loss) on foreign currency derivative	631	130	334	(892)
Net loss	$ (29,597)	$ (15,134)	$ (73,820)	$ (46,239)
Basic and diluted net loss per common share (in dollars per share)	$ (0.28)	$ (0.18)	$ (0.73)	$ (0.58)
Weighted average shares outstanding (in shares)	105,410	83,570	100,955	79,749
Unrealized gain (loss) on available for sale investments	$ 42	$ (2)	$ (167)	$ (5)
Comprehensive loss	(29,555)	(15,136)	(73,987)	(46,244)
Product [Member]
Revenues:
Revenues		1,501		1,501
Royalty [Member]
Revenues:
Revenues	523	442	4,326	7,252
Collaborative and Other Research and Development [Member]
Revenues:
Revenues	$ 931	$ 6,817	$ 13,598	$ 12,543