Consolidated Balance Sheets - USD ($)	Dec. 31, 2015	Dec. 31, 2014
Collaboration Receivables [Member]
ASSETS
Receivables	$ 6,243,000	$ 3,849,000
Trade Accounts Receivable [Member]
ASSETS
Receivables		5,641,000
Deferred Collaborative Revenue [Member]
LIABILITIES AND STOCKHOLDERS’ EQUITY
Deferred revenue	$ 2,163,000	1,481,000
Deferred Product Sales [Member]
LIABILITIES AND STOCKHOLDERS’ EQUITY
Deferred revenue		5,605,000
Cash and cash equivalents	$ 28,899,000	54,540,000
Restricted cash	1,612,000	150,000
Investments	22,664,000	18,232,000
Inventory	1,612,000	683,000
Prepaid expenses and other current assets	4,870,000	6,172,000
Deferred collaboration expense	90,000	76,000
Total current assets	65,990,000	89,343,000
Investments	47,683,000	41,116,000
Property and equipment, net	5,149,000	207,000
Deferred collaboration expense	265,000	177,000
Other assets	5,468,000	6,031,000
Total assets	124,555,000	136,874,000
Accounts payable	9,307,000	2,849,000
Accrued expenses	16,237,000	11,329,000
Interest payable	6,746,000	6,029,000
Non-recourse notes payable	30,000,000	30,000,000
Total current liabilities	64,453,000	57,293,000
Deferred collaboration revenue	9,674,000	3,552,000
Deferred rent	329,000	$ 394,000
Lease financing obligation	2,375
Stockholders’ equity:
Preferred stock, $0.001 par value; shares authorized — 5,000; no shares outstanding	0	$ 0
Common stock, $0.01 par value; shares authorized — 200,000; shares issued and outstanding — 73,355 in 2015 and 71,955 in 2014	734,000	720,000
Additional paid-in capital	558,113,000	542,943,000
Accumulated other comprehensive loss	(206,000)	(130,000)
Accumulated deficit	(510,917,000)	(467,898,000)
Total stockholders’ equity	47,724,000	75,635,000
Total liabilities and stockholders’ equity	$ 124,555,000	$ 136,874,000