Consolidated Statements of Comprehensive Loss (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2014	Sep. 30, 2013	Sep. 30, 2014	Sep. 30, 2013
Revenues
Royalty	$ 5	$ 8	$ 1,951	$ 2,042
Collaborative and other research and development	3,233	2,381	6,211	4,722
Total revenues	3,238	2,389	8,162	6,764
Expenses
Research and development	13,036	7,735	33,286	26,477
General and administrative	1,812	1,579	5,413	4,589
Royalty			78	81
Total operating expenses	14,848	9,314	38,777	31,147
Loss from operations	(11,610)	(6,925)	(30,615)	(24,383)
Interest and other income	14	18	50	72
Interest expense	(1,217)	(1,191)	(3,684)	(3,536)
Gain on foreign currency derivative	4,082	97	732	3,168
Net loss	(8,731)	(8,001)	(33,517)	(24,679)
Basic and diluted net loss per common share (in Dollars per share)	$ (0.12)	$ (0.14)	$ (0.52)	$ (0.46)
Weighted average shares outstanding (in Shares)	71,801	57,124	65,057	53,910
Unrealized loss on investments	(1)	(4)	(2)	(25)
Comprehensive loss	$ (8,732)	$ (8,005)	$ (33,519)	$ (24,704)