Note 1 - Significant Accounting Policies (Details) (USD $) Share data in Thousands, unless otherwise specified	3 Months Ended		9 Months Ended		12 Months Ended	3 Months Ended		9 Months Ended		12 Months Ended	9 Months Ended
	Sep. 30, 2014	Sep. 30, 2013	Sep. 30, 2014	Sep. 30, 2013	Dec. 31, 2013	Sep. 30, 2014 Currency Hedge Agreement [Member]	Sep. 30, 2013 Currency Hedge Agreement [Member]	Sep. 30, 2014 Currency Hedge Agreement [Member]	Sep. 30, 2013 Currency Hedge Agreement [Member]	Dec. 31, 2013 Currency Hedge Agreement [Member]	Sep. 30, 2014 Maximum [Member]	Sep. 30, 2014 Minimum [Member]	Mar. 09, 2011 JPR Royalty Sub LLC [Member]
Note 1 - Significant Accounting Policies (Details) [Line Items]
Investments and Cash	$ 127,586,000		$ 127,586,000
Revenue Recognition Royalty and Milestone Revenue Recognized													30,000,000
Reclassification Adjustments from Research and Development Expense to General and Administrative Expense	242,000		639,000
Maturity Of Investments											3 months
Maturity Period of High Quality Marketable Securities											3 years
Average Maturity Period of High Quality Marketable Securities											18 months
Maturity Period of Short Term Investment											12 months	3 months
Long Term Investment Maturity Minimum												12 months
Accrued Research and Development Expenses			5,090,000		2,210,000
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax			0	0
Interest Expense	1,217,000	1,191,000	3,684,000	3,536,000
Amortization of Financing Costs	110,000	110,000	329,000	329,000
Gain (Loss) on Foreign Currency Derivative Instruments Not Designated as Hedging Instruments	4,082,000	97,000	732,000	3,168,000		4,082,000	97,000	732,000	3,168,000
Cash Collateral Margin Funds								$ 0		$ 0
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in Shares)	5,602	2,783	5,288	1,731
Average Maturity for Portfolio Investments											18 months