X0508 4 2024-05-13 0000882796 BIOCRYST PHARMACEUTICALS INC BCRX 0001584348 Barnes Alane P 4505 EMPEROR BLVD. SUITE 200 DURHAM NC 27703 1 Chief Legal Officer 0 Common Stock 2024-05-13 4 P 0 5000 5.53 A 300762 D The price in column 4 is a weighted average price. These shares were purchased in multiple transactions ranging from $5.36 to $5.64. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares purchased at each price within the range set forth in this footnote. /s/ Alane P. Barnes 2024-05-15