X0508 4 2024-05-13 0000882796 BIOCRYST PHARMACEUTICALS INC BCRX 0001385496 Stonehouse Jon P 4505 EMPEROR BLVD. SUITE 200 DURHAM NC 27703 1 1 President & CEO 0 Common Stock 2024-05-13 4 P 0 30000 5.55 A 1127770 D Common Stock 20000 I By wife as co-trustee of the Caroline Stonehouse Irrevocable Trust Common Stock 20000 I By wife as co-trustee of the Samuel Stonehouse Irrevocable Trust The price in column 4 is a weighted average price. These shares were purchased in multiple transactions ranging from $5.34 to $5.68. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares purchased at each price within the range set forth in this footnote. /s/ Alane P. Barnes, by power of attorney 2024-05-15