X0306 4 2022-03-10 0000882796 BIOCRYST PHARMACEUTICALS INC BCRX 0001439174 Sheridan William P 4505 EMPEROR BLVD. SUITE 200 DURHAM NC 27703 1 Chief Medical Officer Common Stock 2022-03-10 4 M 0 148302 3.22 A 199093 D Common Stock 2022-03-10 4 S 0 159739 16.87 D 39354 D Common Stock 2022-03-10 4 S 0 1400 17.64 D 37954 D Emp. Stock Option (Right to Buy) 3.22 2022-03-10 4 M 0 148302 0 D 2017-05-23 2026-05-23 Common Stock 148302 0 D The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $16.53 to $17.52. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote. The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $17.53 to $17.79. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote. /s/ Alane P. Barnes, by power of attorney 2022-03-14