X0306 4 2021-11-15 0000882796 BIOCRYST PHARMACEUTICALS INC BCRX 0001485939 ABERCROMBIE GEORGE B PO BOX 16069 CHAPEL HILL NC 27516 1 Common Stock 2021-11-15 4 M 0 5000 3.32 A 5000 D Common Stock 2021-11-15 4 S 0 5000 12.27 D 0 D Automatic Stock Option Grant 3.32 2021-11-15 4 M 0 5000 0 D 2022-05-23 Common Stock 5000 10000 D This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 10, 2021. The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $12.22 to $12.29. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote. The option vested 1/12 per month for a period of 12 months, beginning on June 23, 2012. /s/ Alane P. Barnes, by power of attorney 2021-11-17