X0609 4 2026-05-13 0000882796 BIOCRYST PHARMACEUTICALS INC BCRX 0001584348 Barnes Alane P false 4505 EMPEROR BLVD. SUITE 200 DURHAM NC 27703 1 Chief Legal Officer 1 Common Stock 2026-05-13 4 M 0 62500 5.04 A 463203 D Common Stock 2026-05-13 4 S 0 62500 9.54 D 400703 D Emp. Stock Option (Right to Buy) 5.04 2026-05-13 4 M 0 62500 0 D 2018-12-20 2027-12-20 Common Stock 62500 0 D This transaction was made pursuant to a plan adopted by the reporting person on August 13, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. The option grant became exercisable at the rate of 25% on each of the first, second, third, and fourth anniversaries of the date of grant. /s/ Alane P. Barnes 2026-05-15