X0306 4 2021-12-20 0 0000882361 Aptose Biosciences Inc. APTO 0001239414 BURGER DENIS R C/O APTOSE BIOSCIENCES 251 CONSUMERS ROAD, SUITE 1105 TORONTO A6 M2J 4R3 ONTARIO, CANADA 1 0 0 0 Common Shares 2021-12-20 4 P 0 10000 1.449 A 31671 D /s/ Janet Clennett as attorney-in-fact for Denis R. Burger 2021-12-21