X0202 4 2005-05-09 0 0000882104 PROTEIN DESIGN LABS INC/DE PDLI 0000900923 QUEEN CARY L C/O PROTEIN DESIGN LABS, INC. 34801 CAMPUS DRIVE FREMONT CA 94555 1 0 0 0 Common Stock 2005-05-09 4 M 0 10000 6.625 A 2049400 D Common Stock 2005-05-09 4 S 0 10000 18.5289 D 2039400 D Common Stock 3900 I by trust Common Stock 3900 I by trust Common Stock 3900 I by trust Common Stock 3900 I by trust Employee Stock Option (right to buy) 6.625 2005-05-09 4 M 0 10000 0 D 2006-12-14 Common Stock 10000 110000 D Sale was made pursuant to Rule 144. Options vest 1/4 on the first anniversary of the vesting date and thereafter vest 1/48 per month. Only vested options are exercisable. By the Dawn Suisun Queen 1995 Irrevocable Trust. The reporting person disclaims beneficial ownership of all shares owned by such trust, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such shares. By the Heather Kugelmass 1995 Irrevocable Trust. The reporting person disclaims beneficial ownership of all shares owned by such trust, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such shares. By the Bret Kugelmass 1995 Irrevocable Trust. The reporting person disclaims beneficial ownership of all shares owned by such trust, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such shares. By the Rachel Kugelmass 1995 Irrevocable Trust. The reporting person disclaims beneficial ownership of all shares owned by such trust, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such shares. /s/ Sergio Garcia-Rodriguez by Sergio Garcia-Rodriguez, Attorney in Fact for Cary L. Queen 2005-05-10