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PROPERTY, PLANT AND EQUIPMENT
 12 Months Ended
Dec. 31, 2023
Property, Plant and Equipment [Abstract]  
PROPERTY, PLANT AND EQUIPMENT PROPERTY, PLANT AND EQUIPMENT
The following table summarizes our Property, plant and equipment, net by asset type:
December 31,
(in millions)20232022
Land and land improvements$561 $562 
Buildings and improvements (including leasehold improvements)4,328 4,390 
Laboratory and manufacturing equipment1,147 1,110 
Office, computer equipment and other1,069 880 
Construction in progress661 719 
Subtotal7,766 7,661 
Less: accumulated depreciation 2,449 2,186 
Total$5,317 $5,475 
In 2023, we wrote off $381 million of property, plant and equipment related to changes in our manufacturing strategy. The write-offs related primarily to buildings, improvements and related equipment that were determined to be fully impaired based on the difference between fair value and the carrying amount as a result of our decision to no longer utilize the facilities.
The following table summarizes our Property, plant and equipment, net by geography:
December 31,
(in millions)20232022
U.S.$4,691 4,501 
International(1)
626 973 
Total$5,317 $5,475 
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(1)    All individual international locations accounted for less than 10% of the total balances.