CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Millions	6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020
Operating Activities:
Net income (loss)	$ 3,239	$ (1,808)
Adjustments to reconcile net income (loss) to net cash provided by operating activities:
Depreciation expense	157	136
Amortization expense	835	562
Stock-based compensation expense	305	309
Acquired in-process research and development expenses	158	4,621
Deferred income taxes	3	109
Net losses from equity securities	525	82
Other	576	130
Changes in operating assets and liabilities:
Accounts receivable, net	694	368
Inventories	(94)	(22)
Prepaid expenses and other	(2)	76
Accounts payable	(222)	(113)
Income taxes payable	(535)	(361)
Accrued and other liabilities	(713)	(87)
Net cash provided by operating activities	4,926	4,002
Investing Activities:
Purchases of marketable debt securities	(2,078)	(16,753)
Proceeds from sales of marketable debt securities	251	10,426
Proceeds from maturities of marketable debt securities	1,250	6,227
Acquisitions, including in-process research and development, net of cash acquired	(1,347)	(4,804)
Purchases of equity securities	(301)	(86)
Capital expenditures	(284)	(314)
Other	(110)	(63)
Net cash used in investing activities	(2,619)	(5,367)
Financing Activities:
Proceeds from issuances of common stock	100	212
Repurchases of common stock	(352)	(1,382)
Repayments of debt and other obligations	(1,250)	(500)
Payments of dividends	(1,811)	(1,730)
Other	(95)	(85)
Net cash used in financing activities	(3,408)	(3,485)
Effect of exchange rate changes on cash and cash equivalents	(3)	(35)
Net change in cash and cash equivalents	(1,104)	(4,885)
Cash and cash equivalents at beginning of period	5,997	11,631
Cash and cash equivalents at end of period	$ 4,893	$ 6,746