Property, plant and equipment (Tables)

12 Months Ended

Dec. 31, 2019

Property, Plant and Equipment Disclosure [Abstract]

Property, Plant and Equipment

Property, plant and equipment (in millions):

	December 31,
	2019			2018
Land and land improvements	$	404		$	404
Buildings and improvements (including leasehold improvements)	3,358			2,344
Laboratory and manufacturing equipment	805			697
Office and computer equipment	634			558
Construction in progress	723			1,194
Subtotal	5,924			5,197
Less accumulated depreciation and amortization	(1,422		)	(1,191		)
Total	$	4,502		$	4,006