Property, plant and equipment (Tables)

12 Months Ended

Dec. 31, 2018

Property, Plant and Equipment Disclosure [Abstract]

Property, Plant and Equipment

Property, plant and equipment is summarized as follows (in millions):

	December 31,
	2018			2017
Land and land improvements	$	404		$	396
Buildings and improvements (including leasehold improvements)	2,344			2,176
Laboratory and manufacturing equipment	697			533
Office and computer equipment	558			494
Construction in progress	1,194			690
Subtotal	5,197			4,289
Less accumulated depreciation and amortization	(1,191		)	(994		)
Total	$	4,006		$	3,295