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License, Commercialization and Supply Agreements (Details 4) (USD $)
In Millions, except Share data, unless otherwise specified
12 Months Ended 156 Months Ended 12 Months Ended 147 Months Ended
Dec. 31, 2013
Development, license and clinical trial and commercial supply agreement
Mitsubishi Tanabe Pharma Corporation or MTPC
Dec. 31, 2012
Development, license and clinical trial and commercial supply agreement
Mitsubishi Tanabe Pharma Corporation or MTPC
Dec. 31, 2013
Development, license and clinical trial and commercial supply agreement
Mitsubishi Tanabe Pharma Corporation or MTPC
Dec. 31, 2013
Development of Combination Therapy under Assignment Agreement
Dec. 31, 2013
Development of Combination Therapy under Assignment Agreement
License, Commercialization and Supply Agreements          
Milestone payment paid $ 2.0 $ 3.0 $ 15.0    
Cost of products purchased 9.9 7.4      
Potential future milestone payments upon the achievement of threshold sales 6.0        
Threshold sales level for milestone payments 250.0        
Terms of agreement 10 years        
Payments made to date         $ 1.2
Options issued to purchase common stock (in shares)       60,000