Stock Option and Purchase Plans (Tables)

12 Months Ended

Dec. 31, 2013

Stock Option and Purchase Plans

Summary of restricted stock unit award activity

	Number of Restricted Stock Units			Weighted Average Grant Date Fair Value
Restricted stock units outstanding December 31, 2011		—			—
Granted		35,000		$	24.88
Vested		—			—
Forfeited		—			—
Restricted stock units outstanding, December 31, 2012		35,000		$	24.88
Granted		144,500		$	12.63
Vested		(33,296	)		(14.15	)
Forfeited		(146,204	)		(13.83	)
Restricted stock units outstanding, December 31, 2013		—		$	—

Summary of stock option award activity

	Years Ended December 31,
	2013					2012					2011
	Number of Shares			Weighted- Average Exercise Price		Number of Shares			Weighted- Average Exercise Price		Number of Shares			Weighted- Average Exercise Price
Balance at beginning of year		8,510,917		$	10.33		8,575,434		$	6.17		7,919,013		$	5.71
Options:
Granted		4,166,292		$	12.86		2,850,118		$	17.80		1,289,790		$	8.72
Exercised		(2,375,688	)	$	5.79		(2,648,882	)	$	5.00		(482,172	)	$	4.88
Cancelled		(1,395,070	)	$	14.54		(265,753	)	$	9.28		(151,197	)	$	8.32
Balance at end of year		8,906,451		$	12.06		8,510,917		$	10.33		8,575,434		$	6.17
Exercisable at end of year		6,616,555		$	11.00		4,781,301		$	6.32		6,120,210		$	5.38
Weighted average grant-date fair value of options granted during the year				$	8.32				$	11.91				$	5.91

Schedule of stock options outstanding and exercisable, by range of exercise prices

	Options Outstanding					Options Exercisable
Range of Exercise Prices	Number Outstanding at December 31, 2013		Weighted- Average Remaining Contractual Life	Weighted- Average Exercise Price		Number Exercisable December 31, 2013		Weighted- Average Exercise Price
$3.13 - $10.19		3,318,235	3.4 years	$	7.23		3,296,690	$	7.22
$12.04 - $12.84		3,215,931	5.2 years	$	12.29		2,466,649	$	12.22
$12.90 - $25.74		2,372,285	7.1 years	$	18.52		853,216	$	22.08
$3.13 - $25.74		8,906,451	5.1 years	$	12.06		6,616,555	$	11.00

Schedule of estimated share-based compensation expense

Total estimated share-based compensation expense, related to all of the Company's share-based awards, recognized for the years ended December 31, 2013, 2012 and 2011 was comprised as follows (in thousands, except per share data):

	2013		2012		2011
Research and development	$	2,361	$	3,487	$	1,917
Selling, general and administrative		15,964		12,451		5,436
Non-recurring charges		14,072		—		—
Share-based compensation expense before taxes		32,397		15,938		7,353
Related income tax benefits		—		—		—
Share-based compensation expense, net of taxes	$	32,397	$	15,938	$	7,353

Schedule of share-based compensation, net of estimated forfeitures associated with each type of award

   The following table summarizes share-based compensation, net of estimated forfeitures associated with each type of award (in thousands):

	2013		2012		2011
Share-based compensation, net of taxes:
Restricted stock units	$	471	$	292	$	—
Stock options		31,610		15,531		7,259
Employee stock purchase plan		316		115		94
	$	32,397	$	15,938	$	7,353

Schedule of weighted average assumptions used in estimating the fair value of stock options

	2013			2012			2011
Expected life (in years)		4.88			5.54			5.93
Volatility		83.35	%		82.49	%		77.46	%
Risk-free interest rate		1.12	%		1.00	%		2.59	%
Dividend yield		—			—			—