Income Taxes (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2012	Dec. 31, 2011
Deferred tax assets:
Net operating loss carry forwards	$ 154,865	$ 107,241
Research and development credit carry forwards	13,192	14,468
Stock-based compensation	9,386
Accruals and other	5,528	13,197
Depreciation	185	790
Deferred revenue	420
Deferred tax assets, gross	183,576	135,696
Valuation allowance	(183,576)	(135,696)
Total	$ 0	$ 0

The tax effect as of the balance sheet date of the amount of the estimated future tax deductions attributable to income recognized only for tax purposes and which will reverse when recognized under generally accepted accounting principles.

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