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Stock Option and Purchase Plans (Details 4) (USD $)
12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Share-Based Compensation Expense      
Share-based compensation expense before taxes $ 15,938,000 $ 7,353,000 $ 7,413,000
Share-based compensation expense, net of taxes 15,938,000 7,353,000 7,413,000
Restricted stock units
     
Share-Based Compensation Expense      
Share-based compensation expense, net of taxes 292,000    
Net share-based compensation expense, per common share:      
Unrecognized estimated compensation expense 569,000    
Weighted average remaining requisite service period (in months) 2 years 1 month 6 days    
Stock options
     
Share-Based Compensation Expense      
Share-based compensation expense, net of taxes 15,531,000 7,259,000 7,272,000
Net share-based compensation expense, per common share:      
Unrecognized estimated compensation expense 19,900,000    
Weighted average remaining requisite service period (in months) 1 year 2 months 12 days    
Weighted average assumptions for fair value of each option using the Black-Scholes option pricing model      
Expected life (in years) 5.54 5.93 5.82
Volatility (as a percent) 82.49% 77.46% 67.72%
Risk-free interest rate (as a percent) 1.00% 2.59% 2.59%
Employee stock purchase plan
     
Share-Based Compensation Expense      
Share-based compensation expense, net of taxes 115,000 94,000 141,000
Net share-based compensation expense, per common share:      
Unrecognized estimated compensation expense 123,000    
Weighted average remaining requisite service period (in months) 4 years 6 months    
Inventory
     
Share-Based Compensation Expense      
Share-based compensation expense before taxes 196,000    
Continuing Operations:
     
Share-Based Compensation Expense      
Share-based compensation expense before taxes 15,938,000 7,353,000 6,443,000
Continuing Operations: | Research and development
     
Share-Based Compensation Expense      
Share-based compensation expense before taxes 3,487,000 1,917,000 1,204,000
Continuing Operations: | Selling, general and administrative
     
Share-Based Compensation Expense      
Share-based compensation expense before taxes 12,451,000 5,436,000 5,239,000
Discontinued Operations:
     
Share-Based Compensation Expense      
Share-based compensation expense before taxes     970,000
Discontinued Operations: | Cost of goods sold and manufacturing
     
Share-Based Compensation Expense      
Share-based compensation expense before taxes     810,000
Discontinued Operations: | Selling, general and administrative
     
Share-Based Compensation Expense      
Share-based compensation expense before taxes     $ 160,000