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Accrued and other liabilities (Details) (USD $)
In Thousands, unless otherwise specified
Dec. 31, 2012
Dec. 31, 2011
Accrued and other liabilities    
Accrued research and clinical expenses $ 1,372 $ 1,425
Accrued employee compensation and benefits 3,859 3,693
Accrued manufacturing costs 4,135  
Accrued sales and marketing expenses 2,908  
Other accrued liabilities 1,503 1,274
Total $ 13,777 $ 6,392