CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Revenue:
Net product revenue	$ 2,012
Operating expenses:
Cost of goods sold	187
Research and development	32,065	24,604	39,971
Selling, general and administrative	109,665	22,472	25,656
Total operating expenses	141,917	47,076	65,627
Loss from operations	(139,905)	(47,076)	(65,627)
Interest and other income (expense):
Interest and other income, net	199	240	468
Interest expense			(4,308)
Loss on early extinguishment of debt			(5,958)
Total interest and other income (expense)	199	240	(9,798)
Loss from continuing operations before income taxes	(139,706)	(46,836)	(75,425)
Provision for income taxes	(27)	(190)	(9)
Net loss from continuing operations	(139,733)	(47,026)	(75,434)
Net (loss) income from discontinued operations	(148)	886	9,369
Net loss	$ (139,881)	$ (46,140)	$ (66,065)
Basic and diluted net income (loss) per share:
Continuing operations (in dollars per share)	$ (1.42)	$ (0.56)	$ (0.93)
Discontinued operations (in dollars per share)	$ 0.00	$ 0.01	$ 0.11
Net loss per share (in dollars per share)	$ (1.42)	$ (0.55)	$ (0.82)
Shares used in per share computation:
Basic (in shares)	98,289	84,392	81,017
Diluted (in shares)	98,289	84,392	81,017