Stock Option and Purchase Plans (Tables)

12 Months Ended

Dec. 31, 2012

Stock Option and Purchase Plans

Summary of restricted stock unit award activity

	Number of Restricted Stock Units		Weighted Average Grant Date Fair Value		Weighted Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value
Restricted stock units outstanding December 31, 2011		—		—		—		—
Granted		35,000	$	24.88
Vested		—		—
Forfeited		—		—
Restricted stock units outstanding, December 31, 2012		35,000	$	24.88		1.22	$	469,700

Schedule of stock option award activity

	Years Ended December 31,
	2012					2011					2010
	Number of Shares			Weighted- Average Exercise Price		Number of Shares			Weighted- Average Exercise Price		Number of Shares			Weighted- Average Exercise Price
Balance at beginning of year		8,575,434		$	6.17		7,919,013		$	5.71		7,553,776		$	4.74
Options:
Granted		2,850,118		$	17.80		1,289,790		$	8.72		1,729,135		$	9.37
Exercised		(2,648,882	)	$	5.00		(482,172	)	$	4.88		(982,594	)	$	4.34
Cancelled		(265,753	)	$	9.28		(151,197	)	$	8.32		(381,304	)	$	6.66
Balance at end of year		8,510,917		$	10.33		8,575,434		$	6.17		7,919,013		$	5.71
Exercisable at end of year		4,781,301		$	6.32		6,120,210		$	5.38		5,171,827		$	4.82
Weighted average grant-date fair value of options granted during the year				$	11.91				$	5.91				$	5.74

Schedule of stock options outstanding and exercisable, by range of exercise prices

At December 31, 2012, stock options were outstanding and exercisable as follows:

	Options Outstanding					Options Exercisable
Range of Exercise Prices	Number Outstanding at December 31, 2012		Weighted- Average Remaining Contractual Life	Weighted- Average Exercise Price		Number Exercisable December 31, 2012		Weighted- Average Exercise Price
$3.13 - $6.05		3,095,998	5.0 years	$	4.67		3,060,143	$	4.67
$6.10 - $12.04		3,945,660	8.0 years	$	9.99		1,698,417	$	9.08
$18.71 - $25.74		1,469,259	9.4 years	$	23.16		22,741	$	22.63
$3.13 - $25.74		8,510,917	7.2 years	$	10.33		4,781,301	$	6.32

Schedule of estimated share-based compensation expense

 Total estimated share-based compensation expense, related to all of the Company's share-based awards, recognized for the years ended December 31, 2012, 2011 and 2010 was comprised as follows (in thousands, except per share data):

	2012		2011		2010
Continuing Operations:
Research and development	$	3,487	$	1,917	$	1,204
Selling, general and administrative		12,451		5,436		5,239
		15,938		7,353		6,443
Discontinued Operations:
Cost of goods sold and manufacturing		—		—		810
Selling, general and administrative		—		—		160
		—		—		970
Share-based compensation expense before taxes		15,938		7,353		7,413
Related income tax benefits		—		—		—
Share-based compensation expense, net of taxes	$	15,938	$	7,353	$	7,413

Schedule of share-based compensation, net of estimated forfeitures associated with each type of award

 The following table summarizes share-based compensation, net of estimated forfeitures associated with each type of award (in thousands):

	2012		2011		2010
Share-based compensation, net of taxes:
Restricted stock units	$	292	$	—	$	—
Stock options		15,531		7,259		7,272
Employee stock purchase plan		115		94		141
	$	15,938	$	7,353	$	7,413

Schedule of weighted average assumptions used in estimating the fair value of stock options

	2012			2011			2010
Expected life (in years)		5.54			5.93			5.82
Volatility		82.49	%		77.46	%		67.72	%
Risk-free interest rate		1.00	%		2.59	%		2.59	%
Dividend yield		—			—			—