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Accrued and other liabilities (Tables)
12 Months Ended
Dec. 31, 2012
Accrued and other liabilities  
Schedule of accrued and other liabilities

 Accrued and other liabilities consist of (in thousands):

 
  Balance as of  
 
  December 31,
2012
  December 31,
2011
 

Accrued research and clinical expenses

  $ 1,372   $ 1,425  

Accrued employee compensation and benefits

    3,859     3,693  

Accrued manufacturing costs

    4,135      

Accrued sales and marketing expenses

    2,908      

Other accrued liabilities

    1,503     1,274  
           

Total

  $ 13,777   $ 6,392