X0202 4 2007-07-06 0 0000881464 AMYLIN PHARMACEUTICALS INC AMLN 0000903574 GREENE HOWARD E JR 9360 TOWNE CENTRE DR SAN DIEGO CA 92121 1 0 0 0 Common Stock 2007-07-09 4 S 0 3846 42.3309 D 1610834 I by Greene Family Tru Common Stock 66969 I by Greene Child Trus Phantom Stock-Deferred Compensation 2007-07-06 4 A 0 341 42.049 A Common Stock 341 5269 D This sale was affected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. Securities held by the Greene Family Trust Securities held by the Greene Children's Trust The shares of phantom stock will be distributed to the reporting person in the form of Amylin common stock in a lump sum on the earlier of a) six months following the date on which the reporting person no longer serves on Amylin's Board of Directors or b) when the reporting person reaches the age 75. By: /s/Lloyd A. Rowland, Attorney-in-Fact For: Howard E. Greene, Jr. 2007-07-10