Consolidated Statements Of Cash Flows (USD $) In Thousands, unless otherwise specified	3 Months Ended
	Mar. 31, 2012	Mar. 31, 2011
Operating activities:
Net loss	$ (99,040)	$ (37,324)
Adjustments to reconcile net loss to net cash provided by (used for) operating activities:
Depreciation and amortization	24,242	12,888
Interest expense and debt discount accretion on promissory note related to revenue sharing obligation	33,625	0
Accretion of debt discount and amortization of debt issuance costs	5,316	4,575
Employee stock-based compensation	9,158	7,917
Stock-settled compensation accruals	7,698	4,238
Restructuring	0	539
Deferred revenue amortization	(1,875)	(1,875)
Change in fair value of assets and liabilities carried at fair value	9,197	0
Other non-cash expenses	28	27
Changes in operating assets and liabilities:
Accounts receivable	(7,343)	2,719
Inventories	(24,962)	9,110
Other current assets	(3,818)	13,551
Accounts payable and accrued liabilities	11,480	4,162
Accrued compensation	(21,673)	(704)
Payable to collaborative partner	(25,572)	1,505
Deferred collaborative profit-sharing	0	2,808
Restructuring liability	(3,977)	(1,074)
Other assets and liabilities, net	(5,841)	40
Net cash (used for) provided by operating activities	(93,357)	23,102
Investing activities:
Purchases of short-term investments	(184,090)	(62,550)
Sales and maturities of short-term investments	57,334	128,550
Increase (Decrease) in Restricted Cash	(154)	0
Purchases of property, plant and equipment	(10,350)	(10,014)
Increase (decrease) in other long-term assets	(795)	212
Net cash provided by (used for) investing activities	(138,055)	56,198
Financing activities:
Issuance of common stock, net	211,041	4,329
Repayment of notes payable	(6,087)	0
Net cash provided by (used for) financing activities	204,954	4,329
Change in cash and cash equivalents	(26,458)	83,629
Cash and cash equivalents at beginning of period	99,859	164,521
Cash and cash equivalents at end of period	73,401	248,150
Supplemental disclosure of cash flow information:
Property, plant and equipment additions in other current liabilities	255	419
Non-cash dispositions of property, plant and equipment	0	181
Non-cash interest capitalized to property, plant and equipment	2,852	2,648
Non-cash financing activities:
Shares contributed as employer 401(k) match	3,243	3,956
Shares contributed to employee stock ownership plan	$ 13,253	$ 16,456