Licensing Agreements (Details) $ in Millions		1 Months Ended			12 Months Ended
	May. 13, 2013 USD ($)	Dec. 31, 2014 item	Mar. 31, 2014 USD ($)	May. 31, 2013 USD ($)	Dec. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)	Dec. 31, 2013 USD ($)	May. 31, 2015 USD ($)
Upfront and regulatory milestone payments					$ 2.0
Research and development expense related to in-licensing deals					$ 7.5	$ 11.0	$ 5.0
Theravance Biopharma [Member]
Upfront and regulatory milestone payments								$ 6.0
The Medicines Company [Member]
Number of products | item		2
Commitment agreement payment amount						$ 50.5
Zensun [Member]
Commitment agreement payment amount	$ 18.5
Commitment agreement additional payment amount	10.0
Commitment agreement further payments upon approval for new indications of product	$ 25.0
Collateralized loan amount, maximum				$ 12.0
TLC [Member]
Commitment agreement payment amount			$ 39.5